Publications

2025

(211) Li, J., Lee, M., Yang, S., Lewis, J.M., Herisse, M., Pidot, S.J., Scott, N.E., Williams, S.J., A patchwork pathway for catabolism of the sulfosugar sulfucose, bioRxiv [doi link]

(210) Burchill, L., Sharma, M., Madiedo Soler, N., Goddard-Borger, E.D., Davies, G.J., Williams, S.J., Structure, kinetics and mechanism of Pseudomonas putida sulfoquinovose dehydrogenase, the first enzyme in the sulfoglycolytic Entner-Doudoroff pathway, Biochem. J., accepted 13 December 2024.

2024

(209) Burchill, L., Kaur, A., Nastasovici, A., Lee, M., Williams S.J., Structural and kinetic insights into the stereospecific oxidation of 2,3-dihydroxypropanesulfonate by DHPS-3-dehydrogenase from Cupriavidus pinatubonensis, Chem. Sci., 2024,15, 15757-15768. [doi link]

(208) Franklin, A., Salgueiro, V.C., Layton, A.J., Sullivan, R., Mize, T., Vázquez-Iniesta,L., Benedict, S.T., Gurcha, S.S., Anso, I., Besra, G.S., Banzhaf, M., Lovering, A.L., Williams, S.J., Guerin, M.E., Scott, N.E., Prados-Rosales, R., Lowe, E.C., Moynihan, P.J., The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth, Nat. Commun., 2024, 14, 5740. [doi link]

(207) Li, Z., Pickles, I.B., Sharma, M., Melling, B., Pallasdies, L., Codée, J.D.C., Williams, S.J., Overkleeft, H.S., Davies, G.J., Detection of sulfoquinovosidase activity in cell lysates using activity-based probes, Angew. Chem. Int. Ed., 2024, 63, e202401358. [doi link]

(206) Arumapperuma, T., Lee, M., Sharma, M., Zhang, Y., Snow, A., Lingford, J.P., Goddard-Borger, E.D., Davies, G.J., Williams, S.J., Capture-and-release of a sulfoquinovose-binding protein on sulfoquinovose-modified agarose. Org. Biomol. Chem., 2024, 22, 3237-3244. [doi link]

(205) Zudich, L., Leeming, M., Pallasdies, L., Nuske, M., Reid. G., Burchill, L., Williams, S.J., Synthesis of proposed structures and structural revision of marine Roseobacter sulfur amino lipids (SALs). ChemRxiv 2024. [doi link]

(204) Li, J., Mui, J., da Silva, B.M., Pires, D.E.V., Ascher, D.B., Madiedo Soler, N., Goddard-Borger, E.D., Williams, S.J., A broad-spectrum family GH13 α-glucosidase from Marinovum sp., a member of the Roseobacter clade, Appl. Biochem. Biotechnol., 2024, 196, 6059-6071. [doi link]

(203) Nguyen, L.T.A., Bowen, C.J., Burchill, L., Williams, S.J., O’Hair, R.A.J., Differentiation of aminohydroxypropanesulfonic acid structural isomers using tandem mass spectrometry-based methods, J. Am. Soc. Mass Spectrom., 2024, 495, 117148. [doi link]

2023

2022

(192) Burchill, L., Males, A., Kaur, A., Davies, G.J., Williams, S.J., Structure, function and mechanism of N-glycan processing enzymes: endo-α-1,2-mannanase and endo-α-1,2-mannosidase, Isrl. J. Chem., 2022, e202200067. [doi link]

(191) van der Peet, P.L., Joyce, R.D., Ott, H., Marcuccio, S.M., White, J.M., Williams, S.J., Synthesis and structure of clozapine N-oxide hemi(hydrochloride): an infinite hydrogen-bonded poly[n]catenane, Acta Crystallogr. Sect. E., 2022, E78, 1056–1060. [doi link]

(190) Burchill, L., Williams, S.J., Chemistry and biology of the aminosulfonate cysteinolic acid: discovery, distribution, synthesis and metabolism, Org. Biomol. Chem., 2022, 20, 3043-3055. [doi link]

(189) Snow, A.J.D., Sharma, M., Lingford, J.P., Zhang, Y., Mui, J.M.-Y., Epa, R., Goddard-Borger, E.D., Williams, S.J., Davies, G.J., The sulfoquinovosyl glycerol binding protein SmoF binds and accommodates plant sulfolipids, Curr. Res. Struct. Biol., 2022, 4, 51-58. [doi link]

(188) Burchill, L., Zudich, L., van der Peet, P.L., White, J.M., Williams, S.J., Synthesis of the alkylsulfonate metabolites cysteinolic acid, 3-amino-2-hydroxypropanesulfonate and 2,3-dihydroxypropanesulfonate, J. Org. Chem., 2022, 87, 4333–4342. [doi link]

(187) Kaur, A., van der Peet, P.L., Mui, J. W.-Y., Herisse, M., Pidot, S., Williams, S.J., Genome sequences of Arthrobacter spp. that use a modified sulfoglycolytic Embden-Meyerhof-Parnas pathway, Arch. Microbiol., 2022, 204, 193. [doi link]

(186) Burchill, L., Williams, S.J., From the banal to the bizarre: Unravelling immune recognition and response to microbial lipids, Chem. Commun., 2022, 58, 925-940. [doi link]

(185) Sharma, M., Lingford, J.P., Petricevic, M., Snow, A.J.P., Zhang, Y., Järvå, M., Mui, J.W.-Y., Scott, N., Saunders, E., Mao, R., Epa, R., da Silva, B., Pires, D., Ascher, D., McConville, M.J., Davies, G.J., Williams, S.J., Goddard-Borger, E.D., Oxidative desulfurization pathway for complete catabolism of sulfoquinovose by bacteria. Proc. Natl. Acad. Sci. USA, 2022, 119, e2116022119. [doi link]

(184) Frankfater, C., Fujiwara, H., Williams, S.J., Minnaard, A., Hsu, F.-F., Characterization of Mycobacterium tuberculosis Mycolic Acids by Multiple-Stage Linear Ion-Trap Mass Spectrometry, J. Am. Chem. Soc. Mass Spectrom., 2022, 33, 149–159. [doi link]

2021

(183) Snow, A.J.D., Burchill, L., Sharma, M., Davies, G.J., Williams, S.J., Sulfoglycolysis: Catabolic pathways for metabolism of sulfoquinovose, Chem. Soc. Rev., 2021, 50, 13628–13645 [doi link]

(182) Belz, T., Williams, S.J., Synthesis of a glycosylphosphatidylinositol (GPI) fragment as a potential substrate for mannoprotein transglycosidases, Synlett, 2021, 32, 2053-2058. [doi link]

(181) Comprehensive Glycoscience, 2nd Ed, 2021, Eds. Barchi, J., Vidal, S., Williams, S.J., Narain, R., Taniguchi, N., ISBN: 9780128194751, 2964 pages. [doi link]

(180) Jiang, J., Williams, S.J., Editorial overview: Protein–carbohydrate complexes and glycosylation: A new age of discovery in the glycosciences, Curr. Opin. Struct. Biol., 2021, 68, iii-v. [doi link]

(179) Almeida, C.F., Smith, D.G.M., Cheng, T.-Y., Harpur, C.M., Batleska, E., Nguyen-Robertson, C.V., Nguyen, T., Thelemann, T., Reddiex, S.J.J., Li, S., Eckle, S.B.G., Van Rhijn, I., Rossjohn, J., Uldrich, A.P., Moody, D.B., Williams, S.J., Pellicci, D.G., Godfrey, D.I. Benzofuran sulfonates and small self-lipid antigens active type II NKT cell via CD1d, Proc. Natl. Acad. Sci. USA, 2021, 118, e210442011. [doi link]

(178) Alhifthi, A., Williams, S.J., Unimolecular, bimolecular and intramolecular hydrolysis mechanisms of 4-nitrophenyl β-D-glucopyranoside, J. Org. Chem., 2021, 86, 9530-9539. [doi link]

(177) Sharma, M.; Abayakoon, P.; Epa, R.; Jin, Y.; Lingford, J.P.; Tomohiro, S.; Masahiro, N.; Mui, J.W.-Y.; Ishikawa, A.; Goddard-Borger, E.D.; Davies, G.J.; Williams, S.J., Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis. ACS Cent. Sci., 2021, 7, 476-487. [doi link]

(176) Nagata, M., Toyonaga, K., Ishikawa, E., Haji, S., Okahashi, N., Takahashi, M., Izumi, Y., Imamura, A., Takato, K., Ishida, H., Nagai, S., Illarionov, P., Stocker, B. L., Timmer, M. S. M., Smith, D. G. M., Williams, S. J., Bamba, T., Miyamoto, T., Arita, M., Appelmelk, B. J., Yamasaki, S., Helicobacter pylori metabolites exacerbate gastritis through C-type lectin receptors. J. Exp. Med., 2021, 218, e20200815. [doi link]

2020

(175) Sobala, L.F., Fernandes, P.Z., Hakki, Z., Thompson, A.J., Howe, J.D., Hill, M., Zitzmann, N., Davies, S., Stamataki, Z., Butters, T.D., Alonzi, D.S., Williams, S.J., Davies, G.J., Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target, Proc. Natl. Acad. Sci., USA, 2020, 117, 29595-29601. [doi link]

(174) Nguyen, T., Hosono, Y., Shimizu, T., Yamasaki, S., Williams, S.J., Candida albicans steryl 6-O-acyl-α-D-mannosides agonize signalling through Mincle, Chem. Commun., 2020, 56, 15060–15063. [doi link]

(173) Smith, D.G.M., Ito, E., Yamasaki, S., Williams, S.J., Cholesteryl 6-O-acyl-α-glucosides from diverse Helicobacter spp. signal through the C-type lectin receptor Mincle, Org. Biomol. Chem., 2020,18, 7907-7915. [doi link]

(172) Williams, S.J., Goddard-Borger, E.D., α-Glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19, Biochem. Soc. Trans., 2020, 48, 1287–1295. [doi link]

(171) Li, J., Epa, R., Scott, N.E., Skoneczny, D., Sharma, M., Snow, A.J.D., Lingford, J.P., Goddard-Borger, E.D., Davies, G.J., McConville, M.J., Williams, S.J., A sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum bv. trifolii SRDI565, Appl. Environ. Microbiol. 2020, 86, e00750-20. [doi link]

(170) Sobala, L.F., Speciale, G., Zhu, S., Raich, L., Sannikova, N., Thompson, A. J., Hakki, Z., Lu, D., Shamsi Kazem Abadi, S., Lewis, A. R., Rojas-Cervellera, V., Bernardo-Seisdedos, G., Zhang, Y., Millet, O., Jiménez-Barbero, J., Bennett, A. J., Sollogoub, M., Rovira, C., Davies G.J., Williams, S.J., An Epoxide Intermediate in Glycosidase Catalysis, ACS Cent. Sci., 2020, 6, 760-770. [doi link] Comment: ACS Cent. Sci. 2020, 6, 619–621 [doi link]

(169) Smith, D.G.M., Hosono, Y., Nagata, M., Yamasaki, S., Williams, S.J., Design of potent Mincle signalling agonists based on an alkyl β-glucoside template, Chem. Commun., 2020, 56, 4292-4295. [doi link]

(168) Sharma, M., Abayakoon, P., Lingford, J.P., Epa, R., John, A., Jin, Yi, Goddard-Borger, E.D., Davies, G.J., Williams, S.J., Dynamic structural changes accompany the production of dihydroxypropanesulfonate by sulfolactaldehyde reductase, ACS Catalysis, 2020, 10, 2826-2836. [doi link]

(167) Zhang, Y., Mui, J.W.-Y., Arumaperuma, T., Lingford, J.P., Goddard-Borger, E.D., White, J.M., Williams, S.J., Synthesis of sulfoquinovose and sulfoquinovosyl diacylglycerides, and a fluorogenic substrate for sulfoquinovosidases, Org. Biomol. Chem., 2020, 18, 675-686. [doi link]

(166) Burugupalli, S., Almeida, C.F., Smith, D.G.M., Shah, S., Patel, O., Rossjohn, J., Uldrich, A.P., Godfrey, D.I., Williams, S.J., α-Glucuronosyl and α-glucosyl diacylglycerides, natural killer T cell-activating lipids from bacteria and fungi, Chem. Sci., 2020, 11, 2161-2168. [doi link]

(165) Rovira, C., Males, A., Davies, G.J., Williams, S.J., Mannosidase mechanism: At the intersection of conformation and catalysis, Curr. Opin. Struct. Biol., 2020, 62, 79-92. [doi link]

2019

(164) Dumont, L., Richardson, M.B., van der Peet, P., Dixon, M.W.A., Williams, S.J., McConville, M.J., Tilley, L., Cobbold, S.A., The metabolic repair enzyme phosphoglycolate phosphatase regulates central carbon metabolism and fosmidomycin sensitivity in Plasmodium falciparum, mBio, 2019, 10, e02060-19. [doi link]

(163) Almeida, C., Sundararaj, S., Le Nours, J., Praveena, T., Cao, B., Burugupalli, S., Smith, D.G.M., Patel, O., Brigl, M., Pellicci, D.G., Williams, S.J., Uldrich, A.P., Godfrey, D.I., Rossjohn, J., Diversity in the type II Natural Killer T cell receptor repertoire and antigen specificity leads to differing CD1d docking strategies, Nat. Commun., 2019, 10, 5242. [doi link]

(162) Williams, S.J., Methoxyacetic acid esters: Applications in protecting group and glycosylation chemistry, Carbohydr. Res., 2019, 486, 107848. [doi link]

(161) Males, A., Speciale, G., Williams, S.J., Davies, G.J., Distortion of mannoimidazole supports a B_2,5 boat transition state for the family GH125 α-1,6-mannosidase from Clostridium perfringens, Org. Biomol. Chem., 2019, 17, 7863-7869. [doi link]

(160) Sernee, F., Ralton, J., Nero, T.L., Sobala, L., Viera-Lara, M., Kloehn, J., Cobbold, S., Stanton, L., Pires, D.E.V., Hanssen, E., Males, A., Ward, T., Bastidas, L.M., van der Peet, P.L., Parker, M.W., Ascher, D.B., Williams, S.J., Davies, G.J., McConville, M.J., Evolution of a new pathway of reserve carbohydrate biosynthesis in Leishmania parasites. Cell Host Microbe, 2019, 26, 385-399. [doi link] Comment: Trends Parasitol., 2019, 35, 947-949. [doi link]

(159) van der Peet, P.L., Gunawan, C., Watanabe, M., Yamasaki, S., Williams, S.J. Synthetic β-1,2-mannosyloxymannitol glycolipid from the fungus Malassezia pachydermatis signals through human Mincle, J. Org. Chem., 2019, 84, 6788-6797. [doi link]. Correction: [doi link]

(158) Abayakoon, P., Epa, R., Petricevic, M., Bengt, C., Mui, J.W.-Y., van der Peet, P.L., Zhang, Y., Lingford, J.P., White, J.M., Goddard-Borger, E.D., Williams, S.J., Comprehensive synthesis of substrates, intermediates and products of the sulfoglycolytic Embden-Meyerhoff-Parnas pathway, J. Org. Chem., 2019, 84, 2901-2910. [doi link]

(157) Goodger, J.Q.D, Senaratne, S.L., van der Peet, P., Browning, R., Williams, S.J., Nicolle, D., Woodrow, I.E., Eucalyptus subgenus Eucalyptus (Myrtaceae) trees are abundant sources of medicinal pinocembrin and related methylated flavanones, Ind. Crops Prod., 2019, 131, 166-172. [doi link]

(156) van der Peet, P.L., Sandanayake, S., Jarrott, B., Williams, S.J., Discovery of N-aryloxypropylbenzylamines as voltage-gated sodium channel Na_V1.2 subtype selective inhibitors, ChemMedChem, 2019, 14, 570-582. [doi link]

(155) Williams, L.M., He, X., Vaid, T.M., Abdul-Ridha, A., Whitehead, A., Gooley, P.R., Bathgate, R.A.D., Williams, S.J., Scott, D.J., Diazepam is not a direct allosteric modulator of α₁-adrenoceptors, but modulates receptor signalling by inhibiting PDE-4, Pharmacol. Res. Perspect., 2019, e00455. [doi link]

2018

(154) Cartmell, A., Muñoz-Muñoz, J., Briggs, J., Ndeh, D.A., Lowe, E.C., Baslé, A., Terrapon, N., Stott, K., Heunis, T., Gray, J., Yu, L., Dupree, P., Fernandes, P.Z., Shah, S., Williams, S.J., Labourel, A., Trost, M., Henrissat, B., Gilbert, H.J., A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation, Nat. Microbiol., 2018, 3, 1314-1326. [doi link]

(153) Abayakoon, P., Jin, Y., Lingford, J.P., Petricevic, M., John, A., Ryan, E., Mui, J.W.-Y., Pires, D.E.V, Ascher, D.B., Davies, G.J., Goddard-Borger, E.D., Williams, S.J., Structural and biochemical insights into the function and evolution of sulfoquinovosidases, ACS Cent. Sci., 2018, 4, 1266-1273. [doi link]

(152) van der Peet, P.L., Williams, S.J., The synthesis of 1,4-anhydro-α-D-mannopyranose, ChemRxiv, 2018. [doi link]

(151) Williams, S.J., ‘’Carbohydrate Enzymology’ in ‘Encyclopedia of Biophysics’, 9 pages, Springer, Eds. G.C.K. Roberts, A. Watts, 2018, Springer, ISBN: 978-3-642-35943-9. [doi link]

(150) Wilson, K.-E, Limburg, S., Duggan, M., Lawther, A.J., Williams, S.J., Lawrence, A.J., Hale^, M.W., Djouma, E., The galanin receptor-3 antagonist, SNAP 37889, inhibits cue-induced reinstatement of alcohol seeking and increases c-Fos expression in the nucleus accumbens shell of alcohol-preferring rats, J. Psychopharmacol., 2018, 32, 911–921. [doi link]

(149) Schröder, S.P., Kallemeijn, W.W., Debets, M.F., Sobala, L.F., Hakki, Z., Williams, S.J., Beenakker, T.J.M., Aerts, J.M.F.G., van der Marel, G.A., Codée, J.D.C., Davies, G.J., Overkleeft, H.S., Spiro-epoxyglycosides as activity-based probes for glycoside hydrolase family 99 endomannosidase/endomannanase, Chem. Eur. J., 2018, 24, 9983–9992. [doi link]

(148) van der Peet, P.L., Gunawan, C., Abdul-Ridha, A., Ma, S., Scott, D.J., Gundlach, A.L., Bathgate, R.A.D., White, J.M., Williams, S.J., Gram scale preparation of clozapine N-oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs, MethodsX, 2018, 5, 257-267. [doi link]

(147) Abayakoon, P., Lingford, J.P., Jin, Y., Bengt, C., Davies, G.J., Yao, S., Goddard-Borger, E.D., Williams, S.J., Discovery and characterization of a sulfoquinovose mutarotase using kinetic analysis at equilibrium by exchange spectroscopy, Biochem. J., 2018, 16, 1371-1383. [doi link]

(146) Fernandes, P.Z., Petricevic, M., Sobala, L., Davies, G.J., Williams, S.J., Exploration of strategies for mechanism-based inhibitor design for family GH99 endo-α-1,2-mannanases, Chem. Eur. J., 2018, 24, 7464–7473. [doi link]

(145) Thompson, A.J., Spears, R.J., Zhu, Y., Suits, M.D.L., Williams, S.J., Gilbert, H.J., Davies, G.J., Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif, Acta Crystallogr. Sect. D., 2018, 74, 394-404. [doi link]

(144) The Cazypedia Consortium, Ten years of CAZypedia: A living encyclopedia of carbohydrate-active enzymes, Glycobiology, 2018, 28, 3-8. [doi link]

2017

(143) Williams, S.J., Sensing lipids with Mincle: Structure and function, Front. Immunol., 2017, 8, 1662. [doi link]

(142) Alhifthi, A., Harris, B.L., Goerigk, L., White, J.M., Williams, S.J., Structure-reactivity correlations of the abnormal Beckmann reaction of dihydrolevoglucosenone oxime, Org. Biomol. Chem., 2017, 15, 10105–10115. [doi link]

(141) Bellmaine, S., Ovchinnikov, D., Manallack, D.T., Cuddy, C.E., Elefanty, A.G., Stanley, E.G., Wolventang, E.J., Williams, S.J., Pera, M.F., Inhibition of DYRK1A disrupts neural lineage specification in human pluripotent stem cells, eLife, 2017, 6, e24502. [doi link]

(140) Burugupalli, S., Richardson, M.B., Williams, S.J., Total synthesis and mass spectrometric analysis of a Mycobacterium tuberculosis phosphatidylglycerol featuring a two-step synthesis of (R)-tuberculostearic acid, Org. Biomol. Chem., 2017,15, 7422–7429. [doi link]

(139) Smith, D.G.M., Williams, S.J., A carbon tetrachloride-free synthesis of N-phenyltrifluoroacetimidoyl chloride, Carbohydr. Res., 2017, 450, 10–11. [doi link]

(138) Belz, T., Jin, Y., Coines, J., Rovira, C., Davies, G.J., Williams, S.J., An atypical interaction explains the high-affinity of a non-hydrolyzable S-linked 1,6-α-mannanase inhibitor, Chem. Commun., 2017, 53, 9238–9241. [doi link]

(137) Males, A., Raich, L., Williams, S.J., Rovira, C., Davies, G.J., Conformational analysis of the mannosidase inhibitor kifunensine: a quantum mechanical and structural approach, ChemBioChem, 2017, 18, 1496–1501. [doi link]

(136) Osburn, S., Speciale, G., Williams, S.J., O’Hair, R.A.J., Gas-phase intercluster thiyl-radical induced C-H bond homolysis selectively forms sugar C2-radical cations of methyl D-glucopyranoside: isotopic labelling studies and cleavage reactions, J. Am. Soc. Mass Spectrom., 2017, 28, 1425–1431. [doi link]

(135) Daly, S., Choi, C.M., Zavras, A., Krstić, M., Chirot, F., Connell, T.U., Williams, S.J., Donnelly, P.S., Antoine, R., Giuliani, A., Bonačić-Koutecký, V., Dugourd, P., O’Hair, R.A.J., Gas-phase structural and optical properties of homo and heterobimetallic rhombic dodecahedral nanoclusters [Ag_14-nCu_n(C≡CtBu)₁₂X]⁺ (X = Cl and Br): Ion mobility, VUV and UV spectroscopy, and DFT calculations, J. Phys. Chem. C, 2017, 121, 10719–10727. [doi link]

(134) Temple, M.J., Cuskin, F., Baslé, A., Hickey, N., Speciale, G., Williams, S.J., Gilbert, H.J., Lowe, E.C., A Bacteroidetes locus dedicated to fungal 1,6-β-glucan degradation: unique substrate conformation drives specificity of the key endo-1,6-β-glucanase, J. Biol. Chem., 2017, 292, 10639–10650. [doi link]

(133) Kuribara, T., Hirano, M., Speciale, G., Williams, S.J., Ito, Y., Totani, K., Selective manipulation of discrete mannosidase activities in the endoplasmic reticulum by using reciprocally selective inhibitors, ChemBioChem, 2017, 18, 1027–1035. [doi link] Front cover: [doi link]

(132) Scheller, K.J., Lawrence, A.J., Williams, S.J., Djouma, E., The galanin-3 receptor antagonist, SNAP 37889, suppresses alcohol drinking and morphine self-administration in mice, Neuropharmacology, 2017, 118, 1–12. [doi link]

(131) Alonso-Gil, S., Males, A., Fernandes, P.Z., Williams, S.J., Davies, G.J., Rovira, C., Computational design-of-experiment unveils the conformational reaction coordinate of GH125 α-mannosidases, J. Am. Chem. Soc., 2017, 139, 1085−1088. [doi link]

(130) Richardson, M.B., Smith, D.G.M., Williams, S.J., Quantitation in the regioselectivity of acylation of glycosyl diglycerides: Total synthesis of a Streptococcus pneumoniae α-glucosyl diglyceride, Chem. Commun., 2017, 53, 1100–1103. [doi link]

(129) Goddard-Borger, E.D., Williams, S.J., Sulfoquinovose in the biosphere: Occurrence, metabolism and functions, Biochem. J., 2017, 474, 827–849. [doi link]

(128) Petricevic, M., Sobala, L.F., Fernandes, P.Z., Raich, L., Thompson, A.J., Bernardo-Seisdedos, G., Millet, O., Zhu, S., Sollogoub, M., Jiménez-Barbero, J., Rovira, C., Davies, G.J., Williams, S.J., Contribution of shape and charge to the inhibition of a family GH99 endo-α-1,2-mannanase, J. Am. Chem. Soc., 2017, 139, 1089–1097. [doi link]

(127) Ma, S., Allocca, G., Ong-Pålsson, E.K.E., Singleton, C.E., Hawkes, D., McDougall, S.J., Williams, S.J., Bathgate, R.A.D., Gundlach, A.L., Nucleus incertus promotes cortical desynchronization and behavioral arousal, Brain Struct. Function, 2017, 222, 515–537. [doi link]

(126) Cheng. J.M.H., Liu, L., Pellicci, D.G., Reddiex, S., Cotton, R.N., Cheng, T.-Y., Young, D.C., Van Rhijn, I., Moody, D.B., Rossjohn, J., Fairlie, D.P., Godfrey, D.I., Williams, S.J., Total synthesis of the Mycobacterium tuberculosis dideoxymycobactin-838 and stereoisomers: Diverse CD1a-restricted T cells display a common hierarchy of lipopeptide recognition, Chem. Eur. J., 2017, 23, 1694–1701. [doi link]

2016

(125) Jin, Y., Petricevic, M., John, A., Raich, L., Jenkins, H., Portela De Souza, L., Cuskin, F., Gilbert, H.J., Rovira, C., Goddard-Borger, E.D., Williams, S.J., Davies, G.J., A β-mannannase with a lysozyme-like fold and a novel molecular catalytic mechanism, ACS Central Sci., 2016, 2, 896–903. [doi link]

(124) Speciale, G., Farren-Dai, M., Shidmoossavee, F., Williams, S.J., Bennet, A.J., C2-Oxyanion neighboring group participation: Transition state structure for the hydroxide-promoted hydrolysis of 4-nitrophenyl α-D-mannopyranoside, J. Am. Chem. Soc., 2016, 138, 14012−14019. [doi link]

(123) van der Peet, P.L., Nagata, M., Shah, S., White, J.M., Yamasaki, S., Williams, S.J., Lipid structure influences the ability of glucose monocorynomycolate to signal through Mincle, Org. Biomol. Chem., 2016, 14, 9267–9277. [doi link]

(122) Roth, C., Petricevic, M., John, A., Goddard-Borger, E.D., Davies, G.J., Williams, S.J., Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-β-galactosaminidase that uses neighboring group participation, Chem. Commun., 2016, 52, 11096–11099. [doi link]

(121) Shah, S., Nagata, M., Yamasaki, S., Williams, S.J., Total synthesis of a cyclopropane-fatty acid α-glucosyl diglyceride from Lactobacilllus plantarum and identification of its ability to signal through Mincle, Chem. Commun., 2016, 52, 10902–10905. [doi link]

(120) Charoenwattanasatien, R., Pengthaisong, S., Breen, I., Mutoh, R., Sansenya, S., Hua, Y., Tankrathok, A., Wu, L., Songsiriritthigul, C., Tanaka, H., Williams, S.J., Davies, G.J., Kurisua, G., Ketudat Cairns, J.R., Bacterial β-glucosidase reveals the structural and functional basis of genetic defects in human glucocerebrosidase 2 (GBA2), ACS Chem. Biol., 2016, 11, 1891-1900. [doi link]

(119) Sedger, L.M., Tull, D.L., McConville, M.J., De Souza, D.P., Rupasinghe, T.W.T., Williams, S.J., Dayalan, S., Lanzer, D., Mackie, H., Lam, T.C.,  Boyages, J., Lipidomic profiling of adipose tissue reveals an inflammatory signature in cancer-related and primary lymphedema, PLOS One, 2016, 11, e0154650. [doi link]

(118) Belz, T., Williams, S.J., A building block approach to the synthesis of a family of S-linked α-1,6-oligomannosides, Carbohydr. Res., 2016, 429, 38-47. [doi link]

(117) Speciale, G., Jin, Y., Davies, G.J., Williams, S.J., Goddard-Borger, E.D., YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids, Nat. Chem. Biol., 2016, 12, 215-217. [doi link][altmetric]

(116) Davies, G.J., Williams, S.J., Carbohydrate-active enzymes: sequences, shapes, contortions and cells, Biochem. Soc. Trans., 2016, 44, 79-87. [doi link]

(115) Jarrott, B., Williams, S.J., Chronic brain inflammation: The neurochemical basis for drugs to reduce inflammation, Neurochem. Res. 2016, 41, 523-533. [doi link]

(114) Smith, D.G.M., Williams, S.J., Immune sensing of microbial glycolipids and related conjugates by T cells and the pattern recognition receptors MCL and Mincle, Carbohydr. Res., 2016, 420, 32-45. [doi link]

(113) Burugupalli, S., Shah, S., van der Peet, P.L., Arora, S., White, J.M., Williams, S.J., Investigation of benzoyloximes as benzoylating reagents: Benzoyl-Oxyma as a selective benzoylating reagent, Org. Biomol. Chem., 2016, 14, 97-104. [doi link]

2015

(112) Cameron, G., Pellicci, D.G., Uldrich, A.P., Besra, G.S., Illarionov, P., Williams, S.J., LaGruta, N.L., Rossjohn, J., Godfrey, D.I., Antigen specificity of type I Natural Killer T cells is governed by T cell receptor β chain diversity, J. Immunol., 2015, 195, 4604-4614. [doi link]

(111) Tankrathok, A., Iglesias-Fernández, J., Williams, R.J., Pengthaisong, S., Baiya, S., Hakki, Z., Robinson, R.C., Hrmova, M., Rovira, C., Williams, S.J., Kedutat Cairns, J.R., A single glycosidase harnesses different transition state conformations for hydrolysis of mannosides and glucosides, ACS Catalysis, 2015, 5, 6041-6051. [doi link]

(110) Richardson, M.B., Torigoe, S., Yamasaki, S., Williams, S.J., Mycobacterium tuberculosis β-gentiobiosyl diacylglycerides signal through the pattern recognition receptor Mincle: Total synthesis and structure activity relationships, Chem. Commun., 2015, 51, 15027-15030. [doi link]

(109) Cuskin, F., Lowe, E.C., Temple, M.J., Zhu, Y., Cameron, E.A., Pudlo, N.A., Porter, N.T., Urs, K., Thompson, A.J., Cartmell, A., Rogowski, A., Hamilton, B.S., Chen, R., Tolbert, T., Piens, K., Bracke, D.,Vervecken, W., Hakki, Z., Speciale, G., Munōz-Munōz, J.L., Day, A., Peña, M.J., McLean, R., Suits, M.D., Boraston, A.B., Atherly, T., Ziemer, C.J., Williams, S.J., Davies, G.J., Abbott, D.W., Martens, E.C., Gilbert, H.J., Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism, Nature, 2015, 517, 165-169. [doi link] [altmetric]

(108) Thompson, A.J., Speciale, G., Iglesias-Fernández, J., Hakki, Z., Belz, T., Cartmell, A., Spears, R.J., Chandler, E., Temple, M.J., Stepper, J., Gilbert, H.J., Rovira, C., Williams, S.J., Davies, G.J., Evidence for a boat conformation at the transition state of GH76 α-1,6-mannanases–key enzymes in bacterial and fungal mannoprotein metabolism, Angew. Chem. Int. Ed., 2015, 54, 5378-5382. [doi link]

(107) van der Peet, P.L., Gunawan, C., Torigoe, S., Yamasaki, S., Williams, S.J., Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle, Chem. Commun., 2015, 51, 5100-5103. [doi link]

(106) Yamaryo-Botte, Y., Rainczuk, A., Lea-Smith, D., Brammananth, R., van der Peet, P., Meikle, P., Ralton, J.E., Rupasinghe, T.W.T.,  Williams, S.J., Coppel, R.L., Crellin, P.K., McConville, M.J., Acetylation of trehalose mycolates is required for efficient MmpL-mediated surface transport in Corynebacterineae, ACS Chem. Biol., 2015, 10, 734-746. [doi link]

(105) Hakki, Z., Thompson, A.J., Bellmaine, S., Speciale, G., Davies, G.J., Williams, S.J., Structural and kinetic dissection of the endo-α-mannanase activity of bacterial GH99 glycoside hydrolases from Bacteroides spp., Chem. Eur. J., 2015, 21, 1966-1977. [doi link].

(104) Osburn, S., Williams, S.J., O’Hair, R.A.J., Formation of sugar radical cations from collision-induced dissociation of non-covalent complexes with S-nitroso thiyl radical precursors, Int. J. Mass Spectrom., 2015, 378, 95-106. [doi link]

(103) Agostino, M., Velkov, T., Dingjan, T., Williams, S.J., Yuriev, E., Ramsland, P.A., The carbohydrate-binding promiscuity of Euonymus europaeus lectin is predicted to involve a single binding site, Glycobiology, 2015, 25, 101-114. [doi link]

2014

(102) Shah, S., White, J.M., Williams, S.J., Total syntheses of cis-cyclopropane fatty acids: dihydromalvalic acid, dihydrosterculic acid, lactobacillic acid, and 9,10-methylenehexadecanoic acid, Org. Biomol. Chem., 2014, 12, 9427-9438. [doi link]

(101) Scheller, K.J., Williams, S.J., Lawrence, A.J., Jarrott, B., Djouma E., An improved method to prepare an injectable  microemulsion of the galanin-receptor 3 selective antagonist, SNAP 37889, using Kolliphor® HS 15, MethodsX, 2014, 1, 212–216. [doi link]

(100) Holien, J.K., Gazina, E.V., Elliott, R.W., Jarrott, B., Cameron, C.E., Williams, S.J., Parker, M.W., Petrou, S., Computational analysis of amiloride analogue inhibitors of coxsackievirus B3 RNA polymerase, J. Proteomics Bioinform., 2014, S9: 004. [doi link]

(99)  Speciale, G., Thompson, A.J., Davies, G.J., Williams, S.J., Dissecting conformational contributions to glycosidase catalysis and inhibition, Curr. Opin. Struct. Biol., 2014, 28, 1–13. [doi link]

(98)  Connell, T.U., Schieber, C., Proietti Silvestri, I., White, J.M., Williams, S.J., Donnelly, P.S., Copper and silver complexes of tris(triazole)amine and tris(benzimidazole)amine ligands: evidence that catalysis of an azide−alkyne cycloaddition (“click”) reaction by a silver tris(triazole)amine complex arises from copper impurities, Inorg. Chem., 2014, 53, 6503–6511. [doi link]

(97)  Ash, B.L., Quach, T., Williams, S.J., Lawrence, A.J., Djouma, E., Galanin-3 receptor antagonism by SNAP 37889 reduces motivation to self-administer alcohol and attenuates cue-induced reinstatement of alcohol-seeking in iP rats, J. Pharmacol. Sci., 2014, 125, 211–216. [doi link]

(96)  Richardson, M.B., Williams, S.J., MCL and Mincle: C-type lectin receptors that sense damaged self and pathogen associated molecular patterns, Front. Immunol., 2014, 5, 288. [doi link]

(95)  Williams, S.J., Denehy, E.L., Krenske, E.H., Experimental and theoretical insights into the mechanisms of sulfate and sulfamate ester hydrolysis and the end-products of type I sulfatase inactivation by arylsulfamates, J. Org. Chem., 2014, 79, 1995–2005. [doi link]

(94)  Williams, R.J., Iglesias-Fernández, J., Stepper, J., Jackson, A., Thompson, A.J., Lowe, E.C., White, J.M., Gilbert, H.J., Rovira, C., Davies, G.J., Williams, S.J. Combined inhibitor free-energy landscape and structural analysis reports on the mannosidase conformational coordinate, Angew. Chem. Int. Ed., 2014, 53, 1087–1091. [doi link]

2013

(93)  Williams, S.J., Zammit, S.C., Cox, A.J., Shackleford, D.M., Morizzi, J., Zhang, Y., Powell, A.K., Gilbert, R.E., Krum, H., Kelly, D.J., 3’,4’-Bis-difluoromethoxycinnamoylanthranilate (FT061): An orally-activeantifibrotic agent that reduces albuminuria in a rat model of progressive diabetes, Bioorg. Med. Chem. Lett., 2013, 23, 6868-6873. [doi link]

(92)  Lim, N.R., Thomas, C.J., Silva, L.S., Yeap, Y.Y., Yap, S., Bell, J.R., Delbridge, L.M.D., Bogoyevitch, M.A., Woodman, O.L., Williams, S.J., May, C.N., Ng, D.C.H., Cardioprotective 3’,4’-dihydroxyflavonol attenuation of JNK and p38^MAPK signalling involves CaMKII inhibition, Biochem. J., 2013, 45, 149-161. [doi link]

(91)  Richardson, M. B., Williams, S.J., A practical synthesis of long-chain iso-fatty acids (iso-C₁₂–C₁₉) and related natural products, Beilstein J. Org. Chem., 2013, 9, 1807-1812. [doi link]

(90)  van der Peet, P.L., Connell, T.U., Gunawan, C., White, J.M., Donnelly, P.S., Williams, S.J., A click chemistry approach to 5,5’-disubstituted-3,3′-bisisoxazoles from dichloroglyoxime and alkynes: luminescent organometallic iridium and rhenium bisisoxazole complexes, J. Org. Chem., 2013, 78, 7298-7304. [doi link]

(89)  Cao, B., Chen, X., Yamaryo-Botte, Y., Richardson, M.B., Martin, K.L., Khairallah, G.N., Rupasinghe, T.W.T., O’Flaherty, R.M., O’Hair, R.A.J., Ralton, J.E., Crellin, P.K., Coppel, R.L., McConville, M.J., Williams, S.J., Synthesis, structural elucidation and biochemical analysis of immunoactive glucuronosyl diacylglycerides of Mycobacteria and Corynebacteria, J. Org. Chem., 2013, 78, 2175-2190. [doi link]

(88)  Connell, T., Sandanayake, S., Khairallah, G.N., White, J.M., O’Hair, R.A.J., Donnelly, P.S., Williams, S.J., Halide-ion-templated Ag₈Cu₆ rhombic dodecahedrons: Synthesis, structure and reactivity of [Ag₈Cu₆(C≡CtBu)₁₂X]BF₄ (X = Cl, Br), Dalton Trans., 2013, 42, 4903-4907. [doi link]

(87)  Alonzi, D.S., Kukushkin, N.V., Allman, S.A., Hakki, Z., Williams, S.J., Pierce, L., Dwek, R.A., Butters, T.D., Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradative pathway for Golgi-retrieved proteins, Cell. Mol. Life Sci., 2013, 70, 2799-2814. [doi link]

(86)  Zhang, Y., Elsik, M., Edgley, A., Cox, A., Kompa, A.R., Wang, B., Tan, C.Y.R., Khong, F.L., Stapleton, D.I., Zammit, S., Williams, S.J., Gilbert, R.E., Krum, H., Kelly, D.J., A new anti-fibrotic drug attenuates cardiac remodeling and systolic dysfunction following experimental myocardial infarction, Int. J. Cardiol., 2013, 168, 1174-1185. [doi link]

(85)  Williams, S.J., ‘Carbohydrate Enzymology’ in ‘Encyclopedia of Biophysics’, 4 pages, Springer, Ed. Roberts, G.C.K., 2013, Springer, ISBN: 978-3642167119. [link]

(84)  Williams, S.J., Sulfatase Inhibitors: A patent review, Exp. Opin. Ther. Pat., 2013, 23, 79-98. [doi link]

2012

(83)  Gilbert, R.E., Zhang, Y., Williams, S.J., Zammit, S.C., Stapleton, D., Cox, A.J., Krum, H., Langham, R., Kelly, D.J., A purpose-synthesised, anti-fibrotic agent attenuates experimental kidney diseases in the rat, PLoS One, 2012, 7, e47160. [doi link]

(82)  Thompson, A.J., Dabin, J., Iglesias-Fernández, J., Ardèvol, A., Dinev, Z., Williams, S.J., Bande, O., Siriwardena, A., Moreland, C., Hu, T.-C., Smith, D.K., Gilbert, H.J., Rovira, C., Davies, G.J., The reaction coordinate of a bacterial GH47 α-mannosidase: a combined quantum mechanical and structural approach, Angew. Chem. Int. Ed., 2012, 51, 10997-11001. [doi link] Front cover: [doi link]

(81)  Schieber, C., Bestetti, A., Lim, J.P., Ryan, A., Nguyen, T.-L., Eldridge, R., White, A.R., Gleeson, P.A., Donnelly, P.S., Williams, S.J., Mulvaney, P., Conjugation of transferrin to azide-modified CdSe/ZnS core-shell quantum dots using cyclooctyne click chemistry, Angew. Chem. Int. Ed., 2012, 51, 10523-10527. [doi link]

(80)  Quach, T., Tsegay, S., Thompson, A.J., Kukushkin, N.V., Alonzi, D.S., Butters, T.D., Davies, G.J., Williams, S.J., Fleetamine (3-O-α-D-glucopyranosyl-swainsonine): The synthesis of a hypothetical inhibitor of endo-α-mannosidase, Tetrahedron: Asymmetry, 2012, 23, 992-997. [doi link]

(79)  Heskes, A.M., Goodger, J.Q.D., Tsegay, S., Quach, T., Williams, S.J., Woodrow, I.E., Localization of oleuropeyl glucose esters and flavanone to essential oil secretory cavities of Myrtaceae, PLoS One, 2012,7, e40856. [doi link]

(78)  Tan, S.M., Zhang, Y., Wang, B., Tan, C.Y.R., Zammit, S.C., Williams, S.J., Krum, H., & Kelly, D.J., An orally active anti-fibrotic compound, FT23, attenuates structural and functional abnormalities in an experimental model of diabetic cardiomyopathy, Clin. Exp. Pharmacol. Physiol., 2012, 38, 650-656. [doi link]

(77)  Tsegay, S., Williams, R.J., Williams, S.J., Synthesis of glycosyl fluorides from thio-, seleno-, and telluroglycosides and glycosyl sulfoxides using aminodifluorosulfinium tetrafluoroborates, Carbohydr. Res., 2012, 357, 16-22. [doi link]

(76)  Tilley, A.J., Zanatta, S.D., Qin, C.X., Kim, I.-K., Seok, Y.-M., Stewart, A., Woodman, O.L., Williams, S.J., 2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol,equol and analogues: Vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition, Bioorg. Med. Chem., 2012, 20, 2353–2361. [doi link]

(75)  Zhang, Y., Edgley, A.J., Cox, A.J., Powell, A.K., Wang, B., Kompa, A.R., Stapleton, D.I., Zammit, S.C., Williams, S.J., Krum, H., Gilbert, R.E., Kelly, D.J., FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy, Eur. J. Heart Failure, 2012, 14, 549-562. [doi link]

(74)  van der Peet, P., Ralton, J.E., McConville, M.J., Williams, S.J., Discovery of inhibitors of Leishmania β-1,2-mannosyltransferases using a click-chemistry-derived guanosine monophosphate library, PLoS One, 2012, 7, e32642. [doi link]

(73)  Thompson, A.J., Williams, R.J., Hakki, Z., Alonzi, D.S., Wennekes, T., Gloster, T.M., Songsrirote, K., Thomas-Oates, J.E., Wrodnigg, T.M., Spreitz, J., Stütz, A.E., Butters, T.D., Williams, S.J., Davies, G.J., Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase, Proc. Natl. Acad. Sci. USA., 2012, 109, 781-786. [doi link]

(72)  Kim, H.Y., Seok, Y.M., Woodman, O.L., Williams, S.J., Kim, I.K., 3’,4’-Dihydroxyflavonol reduces vascular contraction through Ca²⁺ desensitization in permeabilized rat mesenteric artery, Naunyn-Schmiedeberg’s Arch. Pharmacol., 2012, 385, 191-202. [doi link]

2011

(71)  Qin, C.X., Williams, S.J., Woodman, O.L., Antioxidant activity contributes to flavonol cardioprotection during reperfusion of rat hearts, Free Radical Biol. Med., 2011, 51, 1437-1444. [doi link]

(70)  Proietti Silvestri, I., Andemarian, F., Khairallah, G.N., Yap, S.W., Quach, T., Tsegay, S., Williams, C.M., O’Hair, R.A.J., Donnelly, P.S., Williams, S.J., Copper(I)-catalyzed cycloaddition of silver acetylides and azides: Incorporation of volatile acetylenes into the triazole core, Org. Biomol. Chem., 2011, 9, 6082-6088. [doi link]

(69)  Uldrich, A.P., Patel, O., Cameron, G., Pellicci, D.G., Day, E.B., Sullivan, L.C., Kyparissoudis, K., Kjer-Nielsen, L., Vivian, J.P., Cao, B., Brooks, A.G., Williams, S.J., Illarionov, P., Besra, G.S., Turner, S.J.,Porcelli, S.A., McCluskey, J., Smyth, M.J., Rossjohn, J., Godfrey, D.I., A semi-invariant Va10⁺ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen–recognition properties, Nat. Immunol., 2011, 12, 616-623. [doi link]

(68)  Yap, S., Woodman, O.L., Crack, P.J., Williams, S.J., Synthesis of a hypoxia-targeted conjugate of the cardioprotective agent 3′,4′-dihydroxyflavonol and evaluation of its ability to reduce ischaemia/reperfusion injury, Bioorg. Med. Chem. Lett., 2011, 21, 5102-5106. [doi link]

(67)  Chen, X., Khairallah, G.N., O’Hair, R.A.J., Williams, S.J., Fixed-charge labels for simplified reaction analysis: 5-hydroxy-1,2,3-triazoles as byproducts of a copper(I)-catalyzed click reaction, Tetrahedron Lett., 2011, 52, 2750-2753. [doi link]

(66)  Cao, B., White, J.M., Williams, S.J., Synthesis of glycoconjugate fragments of mycobacterial phosphatidylinositol mannosides and lipomannan, Beilstein J. Org. Chem., 2011, 7, 369-377. [doi link]

(65)  Williams, S.J., Thomas, C.J., Boujaoude, M., Gannon, C.T., Zanatta, S.D., Jarrott, B., May, C.N., Woodman, O.L., Water soluble flavonol prodrugs that protect against ischaemia-reperfusion injury in rat hindlimb and sheep heart, Med. Chem. Comm., 2011, 2, 321-324. [doi link]

(64)  Ash, B., Zanatta, S.D., Williams, S.J., Lawrence, A.J., Djouma, E. The galanin-3 antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats, Regulatory Peptides, 2011, 166, 59-67. [doi link]

2010

(63)  Gao, X., Williams, S.J., Woodman, O.L., Marriott, P.J., Comprehensive two-dimensional gas chromatography, retention indices and time-of-flight mass spectra of flavonoids and chalcones, J. Chromatogr. A, 2010, 1217, 8317-826. [doi link]

(62)  Hakki, Z., Cao, B., Heskes, A.M., Goodger, J.Q.D., Woodrow, I.E., Williams, S.J., Synthesis of the monoterpenoid esters cypellocarpin C and cuniloside B and evidence for their widespread occurrence in eucalyptus, Carbohydr. Res., 2010, 345, 2079-2084. [doi link]

(61)  Williams, R.J., McGill, N.W., White, J.M., Williams, S.J., Neighboring group participation in glycosylation reactions by 2,6-disubstituted 2-O-benzoyl groups: A mechanistic investigation, J. Carbohydr. Chem., 2010, 29, 236-263. [doi link]

(60)  Cao, B., Williams, S.J., Chemical approaches for the study of the mycobacterial glycolipids phosphatidylinositol mannosides, lipomannan and lipoarabinomannan, Nat. Prod. Rep., 2010, 27, 919-947. [doilink]

(59)  Song, M.-J., Baek, I., Seo, M., Kim, S.-H., Suk, K., Woodman, O.L., Williams, S.J., Kim, I. K., Effects of 3′,4′-dihydroxyflavonol on vascular contractions of rat aortic rings, Clin. Exper. Pharmacol. Physiol., 2010, 37, 803-810. [doi link]

(58)  Shirbin, S.J., Boughton, B.A., Zammit, S.C., Zanatta, S.D., Marcuccio, S.M., Hutton, C.A., Williams, S.J., Copper-free palladium-catalyzed Sonogashira and Hiyama cross-couplings using aryl imidazol-1-yl sulfonates, Tetrahedron Lett., 2010, 51, 2971-2974. [doi link]

(57)  Zhu, Y., Suits, M.D.L., Thompson, A.J., Chavan, S., Dinev, Z., Dumon, C., Smith, N., Moremen, K.W., Xiang, Y., Siriwardena, A., Williams, S.J., Gilbert, H.J., Davies, G.J., Mechanistic insights into a Ca²⁺-dependent family of α-mannosidases in a human gut symbiont, Nat. Chem. Biol., 2010, 6, 125-132. [doi link]

(56)  Zanatta, S.D., Jarrott, B., Williams, S.J., Synthesis and preliminary pharmacological evaluation of aryl dithiolethiones with cyclooxygenase-2-selective inhibitory activity and hydrogen sulfide-releasing properties, Aust. J. Chem., 2010, 63, 946-957. [doi link]

2009

(55)  McGill, N.W., Williams, S.J., 2,6-Disubstituted benzoates as neighboring groups for enhanced diastereoselectivity in β-galactosylation reactions: Synthesis of β-1,3-linked oligogalactosides related to arabinogalactan proteins, J. Org. Chem., 2009, 74, 9388-9398. [doi link]

(54)  Zammit, S.C., Cox, A.J., Gow, R.M., Zhang, Y., Gilbert, R.E., Krum, H., Kelly, D.J., Williams, S.J., Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates, Bioorg. Med. Chem. Lett., 2009, 19, 7003-7006. [doi link]

(53)  Goodger, J.Q.D., Cao, B., Jayadi, I., Williams, S.J., Woodrow, I.E., Non-volatile components of the essential oil secretory cavities of Eucalyptus leaves: discovery of two glucose monoterpene esters, cuniloside B and froggattiside A, Phytochemistry, 2009, 70, 1187-1194. [doi link]

(52)  Zannata, S.D., Manallack, D.T., Jarrott, B., Williams, S.J., Synthesis and evaluation of dithiolethiones as novel cyclooxygenase inhibitors, Bioorg. Med. Chem. Lett., 2009, 19, 459-461. [doi link]

(51)  Bojarová, P., Williams, S.J., Aryl sulfamates are broad spectrum inactivators of sulfatases: Effects on sulfatases from various sources, Bioorg. Med. Chem. Lett., 2009, 19, 477-480. [doi link]

(50)  Loft, K.J., Bojarová, P., Slámová, K., Křen, V., Williams, S.J., Synthesis of sulfated glucosaminides for profiling substrate specificities of sulfatases and fungal β-N-acetylhexosaminidases, ChemBioChem, 2009, 10, 565-576. [doi link]

(49)  Williams, S.J., ‘Glycoconjugate Structure and Biosynthesis’, in ‘Wiley Encyclopedia of Chemical Biology’, Ed. Begley, T.P., 2009, 4 volumes, 3188 pages, 260 chapters, John Wiley and Sons, pp1-14,. ISBN: 978-0-471-75477-0. [doi link]

(48)  Stick, R.V., and Williams, S.J., ‘Carbohydrates. The Essential Molecules of Life’, 2009, 474 pages, ISBN 978-0-240-52118-3, Elsevier, Oxford: United Kingdom. [link]

2008

(47)  Watt, J.A., Gannon, C.T., Loft, K.J., Dinev, Z., Williams, S.J., “Click” preparation of carbohydrate 1-benzotriazoles, 1,4-disubstituted and 1,4,5-trisubstituted triazoles and their utility as glycosyl donors, Aust. J. Chem., 2008, 61, 837-846. [doi link]

(46)  Yap, S., Loft, K.J., Woodman, O.L., Williams, S.J., Discovery of water soluble antioxidant flavonols without vasorelaxant activity, ChemMedChem, 2008, 3, 1572-1579. [doi link]

(45)  Bojarová, P., Williams, S.J., Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination, Curr. Opin. Chem. Biol., 2008, 12, 573-581. [doi link]

(44)  McGill, N., and Williams, S.J., ‘Anhydro sugars’ in ‘Glycoscience: Chemistry and Chemical Biology’, Ed. Fraser-Reid, B.O., Tatsuta, K., Thiem, J., Coté, G.L., Flitsch, S., Ito, Y., Kondo, H., Nishimura, S.-i., Yu, B., 2^nd Ed, 2008, Vol. I, Springer: Heidelberg, ISBN 978-3-540-36157-2. [doi link]

(43)  Bojarova, P., Denehy, E., Walker, I., Loft, K., De Souza, D.P., Woo, L.W., Potter, B.V.L., McConville, M.J., Williams, S.J., Direct evidence for ArO-S bond cleavage upon inactivation of Pseudomonas aeruginosa arylsulfatase by aryl sulfamates, ChemBioChem, 2008, 9, 613-623. [doi link]

(42)  Qin, C., Chen, X., Hughes, R.A., Williams, S.J., Woodman, O.L., Understanding the cardioprotective effects of flavonols: Discovery of relaxant flavonols without antioxidant activity, J. Med. Chem., 2008, 51, 1874-1884. [doi link]

(41)  Donnelly, P.S., Zanatta, S.D., Zammit, S.C., White, J.M., Williams, S.J., “Click” cycloaddition catalysts: Copper(I) and copper(II) tris-(triazolylmethyl)amine complexes, Chem. Commun., 2008, 2459-2461.[doi link]

2007

(40)  Dinev, Z., Gannon, C. T., Egan, C., Watt, J. A., McConville, M. J. and Williams, S. J., Galactose-derived phosphonate analogues as potential inhibitors of phosphatidylinositol biosynthesis in mycobacteria, Org. Biomol. Chem., 2007, 5, 952-959. [doi link]

(39)  Senaratne, R.H., Mougous, J.D., Reader, J.R., Williams, S.J., Zhang, T., Bertozzi, C.R. and Riley, L.W., Vaccine efficacy of attenuated but persistent Mycobacterium tuberculosis cysH mutant, J. Med. Microbiol., 2007, 56, 454-458. [doi link]

(38)  Wicki, J., Williams, S.J., Withers, S.G., Transition-state mimicry by glycosidase inhibitors: A critical kinetic analysis, J. Am. Chem. Soc., 2007, 129, 4530-4531. [doi link]

(37)  Denehy, E., White, J.M., Williams, S.J., The electronic structure of the sulfonyl and phosphonyl groups: A computational and crystallographic study, Inorg. Chem., 2007, 46, 8871-8886.[doi link]

(36)  Loft, K. and Williams, S.J., ‘Complex carbohydrate modifying enzymes’ in ‘Glycobiology’, Ed. C. Sansom and O. Markman. 2007, pp.202-216, Scion: Bloxham: United Kingdom.

2006

(35)  Denehy, E., White, J.M., Williams, S.J., Ground state structures of sulfate monoesters and sulfamates reveal similar reaction coordinates for sulfuryl and sulfamyl transfer, Chem. Commun., 2006, 314-316.[doi link]

(34)  Williams, S.J., Hekmat, O., Withers, S.G., Synthesis and testing of mechanism-based protein-profiling probes for retaining endo-glycosidases, ChemBioChem, 2006, 7, 116-124. [doilink]

(33)  Senaratne, R.H., De Silva, A.D., Williams, S.J., Mougous, J.D., Reader, J.R., Zhang, T., Chan, S., Sidders, B., Lee, D.H., Chan, J., Bertozzi, C.R., Riley, L.W., 5’-Adenosinephosphosulfate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic infection phase in mice, Mol. Microbiol., 2006, 59, 1744-1753. [doi link]

(32)  Dinev, Z., Wardak, A.Z., Brownlee, R.T.C., Williams, S.J., A convenient gram-scale synthesis of uridine diphospho(¹³C₆)glucose, Carbohydr. Res., 2006, 341, 1743-1747. [doi link]

(31)  Sernee, F. M., Ralton, J. E., Dinev, Z., Khairallah, G. N., O’Hair, R. A. J., Williams, S. J. and McConville, M. J., Biosynthesis of Leishmania mannan is primed by a novel mannose-cyclic phosphate, Proc. Natl. Acad. Sci. USA, 2006, 103, 9458-9463. [doi link]

(30)  van der Peet, P., Gannon, C.T., Walker, I., Dinev, Z., Angelin, M., Tam, S., Ralton, J.E., McConville, M.J., Williams, S.J., Use of click chemistry to define the substrate specificity of Leishmania β-1,2-mannosyltransferases, ChemBioChem, 2006, 7, 1384-1391. [doi link]

2005

(29)  Watt, J.A., Williams, S.J., Rapid, iterative assembly of octyl α-1,6-oligomannosides and their 6-deoxy equivalents, Org. Biomol. Chem., 3. 2005, 1982-1992. [doi link]

(28)  Morita, Y.S., Velasquez, R., Taig, E., Waller, R.F., Patterson, J.H., Tull, D., Williams, S.J. Billman-Jacobe, H., McConville, M.J., Compartmentalization of lipid biosynthesis in mycobacteria, J. Biol. Chem., 2005, 280, 21645-21652. [doi link]

(27)  Hekmat, O., Kim, Y-W., Williams, S.J., He, S., Withers, S.G., Active-site peptide ‘fingerprinting’ of glycosidases in complex mixtures by mass spectrometry: Discovery of a novel retaining β-1,4-glycanase in Cellulomonas fimi, J. Biol. Chem., 2005, 280, 35126-35135. [doi link]

(26)  Williams, S.J. ‘Trifluoromethanesulfonic anhydride’ in ‘Handbook of Reagents for Organic Synthesis: Reagents for Glycoside, Nucleotide, and Peptide Synthesis’, Ed. Crich, D., 2005, pp. 634-642, John Wiley and Sons: Chichester, England.

2004

(25)  Woodruff, P.J., Carlson, B.L., Siridechadilok, B., Pratt, M.R., Senaratne, R.H., Mougous, J.D., Riley, L.W., Williams, S.J., Bertozzi C.R., Trehalose is required for growth of Mycobacterium smegmatis, J. Biol. Chem. 2004, 279, 28835-28843. [doi link]

(24)  Gloster, T., Williams, S.J., Roberts, S., Tarling, C.A., Wicki, J., Withers, S.G., Davies, G.J., Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A, Chem. Commun., 2004, 1794-1795. [doi link]

2003

(23)  Gloster, T., Williams, S.J., Tarling, C.A., Roberts, S., Dupont, C., Jodoin, P., Shareck, F., Withers, S.G., Davies, G.J., A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomer, Chem. Commun., 2003, 944-945. [doi link]

(22)  Williams, S.J., Best, J.D., Novel microsomal triglyceride transfer protein inhibitors, Exp. Opin. Ther. Pat., 2003, 13, 479-488.

2002

(21)  Notenboom, V., Boraston, A.B. Williams, S.J., Kilburn, D.G., Rose, D.R.; High-resolution crystal structures of the lectin-like xylan binding domain from Streptomyces lividans Xylanase 10A with bound substrates reveal a novel mode of xylan binding, Biochemistry, 2002, 41, 4246-4254. [doi link]

(20)  Williams, S.J., Withers, S.G., Glycosynthases: Mutant glycosidases for glycoside synthesis, Aust. J. Chem., 2002, 55, 3-12. [doi link]

(19)  Mougous, J.D., Green, R.E., Williams, S.J., Brenner, S.E., Bertozzi, C.R., Sulfotransferases and sulfatases in mycobacteria, Chem. Biol., 2002, 9, 767-776. [doi link]

(18)  Williams, S.J., Senaratne, R.H., Mougous, J.D., Riley, L.W., Bertozzi, C.R., 5’-Adenosinephosphosulfate lies at a metabolic branchpoint in mycobacteria, J. Biol. Chem., 2002, 277, 32606-32615. [doi link]

(17)  Williams, S.J., Mark, B.L., Vocadlo, D.J., James, M.N.G., Withers, S.G., Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state, J. Biol. Chem., 2002, 277, 40055-40065. [doi link]

(16)  Mougous, J.D., Leavell, M.D., Senaratne, R.H., Leigh, C.D., Williams, S.J., Riley, L.W., Leary, J.A., Bertozzi, C.R., Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach, Proc. Natl. Acad. Sci. USA, 2002, 99, 17037-17042. [doi link]

2001

(15)  Stick, R.V., and Williams, S.J., ‘Anomeric Anhydro Sugars’, ‘Glycoscience: Chemistry and Chemical Biology’, Ed. Fraser-Reid, B.O., Tatsuta, K., and Thiem, J., 2001, Vol. I, 627-642, Springer-Verlag: Heidelberg.

(14)  Williams, S.J., Davies, G.J., Protein-carbohydrate interactions: Learning lessons from nature, Trends Biotechnol., 2001, 19, 356-362. [doi link]

2000

(13)  Skelton, B., Stick, R.V., Tilbrook, D.M.G., White, A.H., Williams, S.J., Investigations into the chemistry of some 1,6-epithio- and 1,6-episeleno-β-D-glucopyranoses, Aust. J. Chem., 2000, 53, 389-397. [doi link]

(12)  Williams, S.J., Hoos, R., Withers, S.G., Nanomolar versus millimolar inhibition by xylobiose-derived azasugars: Significant differences between two structurally distinct xylanases, J. Am. Chem. Soc., 2000,122, 2223-2235. [doi link]

(11)  Williams, S.J., Notenboom, V., Wicki, J., Rose, D.R., Withers, S.G., A new, simple, high affinity glycosidase inhibitor: Analysis of binding through X-ray crystallography, mutagenesis, and kinetic analysis, J. Am. Chem. Soc., 2000, 122, 4229-4230. [doi link]

(10)  Notenboom, V., Williams, S.J., Hoos, R., Withers, S.G., Rose, D.R., Detailed structural analysis of glycosidase/inhibitor interactions: complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars, Biochemistry, 2000, 39, 11553-11563. [doi link]

(9)    Williams, S.J., Withers, S.G., Glycosyl fluorides in enzymatic reactions, Carbohydr. Res., 2000, 327, 27-46. [doi link]

1995-1999

(8)    Stick, R.V., Tilbrook, D.M.G., Williams, S.J., β-Acarbose VIII: The synthesis of some N-linked carba-oligosaccharides, Aust. J. Chem., 1999, 52, 895-904. [doi link]

(7)    Stick, R.V., Tilbrook, D.M.G., Williams, S.J., β-Acarbose VII: Synthetic approaches towards the synthesis of some N-linked carba-oligosaccharides, Aust. J. Chem., 1999, 52, 885-894. [doi link]

(6)    Stick, R.V., Tilbrook, D.M.G., Williams, S.J., 1,6-Epithio- and 1,6-episeleno-β-D-glucopyranose: Useful adjuncts in the synthesis of 6-deoxy-β-D-glucosides, Aust. J. Chem., 1999,52, 685-693. [doi link]

(5)    Stick, R.V., Tilbrook, D.M.G., Williams, S.J., The synthesis of some seleno- and telluro-β-D-glucopyranosides, Aust. J. Chem, 1997, 50, 233-235. [doi link]

(4)    Stick, R.V., Tilbrook, D.M.G., Williams, S.J., The selective activation of telluro- over seleno-β-D-glucopyranosides as glycosyl donors: A reactivity scale for various telluro-, seleno- and thio sugars, Aust. J.Chem, 1997, 50, 237-240. [doi link]

(3)    Stick, R.V., Tilbrook, D.M.G., Williams, S.J., 1,6-Epithio- and 1,6-episeleno-β-D-glucopyranose: Useful adjuncts in the synthesis of 6-deoxy-β-D-glucosides, Tetrahedron Lett., 1997,38, 2741-2744.

(2)    Bouchet, F., Driguez, H., McAuliffe, J.C., Stick, R.V., Tilbrook, D.M.G., Williams S.J., A new approach to some 1,6-dideoxy 1,6-epithio sugars, Aust. J. Chem., 1996, 49, 343-348.[doi link]

(1)    Brunow, G., Stick, R.V., Syrjänen, K., Tilbrook, D.M.G., Williams S.J., A synthesis of (Z)-9-octadecenedioic acid, Aust. J. Chem., 1995, 48, 1893-1897. [doi link]

Patents

(1) Bertozzi, C.R., Williams, S.J., Mougous, J.D. ‘Mycobacterial sulfation pathway proteins and methods of use thereof’, PCT Int. Appl. (2003), US 2003180321.

(2) Yap, S. W., Williams, S. J. and Woodman, O. L., ‘Improved flavonols’, AU PCT (2006), 2006233256.

(3) Zammit, S., Gilbert, R.E., Krum, H., Stapleton, D., Williams, S.J., and Kelly, D. J., ‘Preparation of cinnamoyl anthranilates and analogs thereof with antifibrotic activity’, PCT Intl. Appl. (2008), WO 2008003141 A1  20080110; US 20100130497.

(4) Jarrott, B., Zanatta, S.D., Williams, S.J., ‘Dithiole compounds as Cox inhibitors’ WO 2008052288, A1 20080508, PCT Int. Appl. (2008).

(5) Kelly, D.J., Williams, S.J., Zammit, S., Halogenated cinnamoylbenzamide analogs of anti-fibrotic agents and their preparation’, PCT Int. Appl. (2009), WO 2009079692, A1 20090702.

(6) Williams, S.J., Zammit, S., Kelly, D.J., James, I.W. ‘(Hetero)aryl compounds as antifibrotic agents and their preparation, pharmaceutical compositions and use in the treatment of fibrosis’,  (2010), WO 2010144959

(7) Williams, S.J., Zammit, S., Kelly, D.J., ‘Fused ring analogues of anti-fibrotic agents and synthesis and use for treatment of fibrosis, inflammation and malignant neoplastic disease’, PCT Int. Appl. (2011), WO 2011047432 A1 20110428.

(8) Williams, S.J., Donnelly, P.S., Mulvaney, P., Schieber, C., Jimenez, I.O., ‘Preparation of bicyclo[6.1.0]non-4-yne compounds suitable for use as linkers in biological applications’, PCT Int. Appl. (2013), WO 2013181697 A1 20131212.

(9) Blencowe, A.R., Dunstan, D.E., Qiao, G.G., Bekard, I.B., Karas, J.A., van der Peet, P.L., Ow, S.-Y., Williams, S.J., Inhibition of amyloid fibril formation, PCT Int. Appl. (2014), WO 2014190398 A1 20141204

(10) Donnelly, P.S., Rudd, S.E., Williams, S.J., Novel hydroxamic acid-based imaging composition and uses thereof, PCT Int. Appl. (2016), WO 2016058056 A1 20160421.

(11) Williams, S.J., Jarrott, B., Aryloxyalkylamine derivatives as sodium channel modulators and their preparation, PCT Int. Appl. (2016), WO 2016149765 A1 20160929.

Book Reviews

(12)   Williams, S.J., Withers, S.G., ‘Essentials of carbohydrate chemistry and biochemistry’ by Thisbe Lindhorst’, Book Review, Angew. Chem. Int. Ed., 2000, 39, 3143-3144.

(13)   Williams, S.J. ‘Peptides and proteins’ by Shawn Doonan, Book Review, Aust. J. Chem., 2003, 56, 839. [doi link]

Commentaries and Essays

(14)  Williams, S.J., Davies, G.J. ‘A master of its sulfate’, Nature Struct. Mol. Biol., 2004, 11, 686-687. Commentary for ‘Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis’. [doi link]

(15)  Williams, S.J., ‘Robert Vyent Stick: A Colourful Character’, Aust. J. Chem. 2009, 62, 503-509. [doi link]

(16)  Coombe, D.R., Davis, C., Fincher, G., McConville, M.J., Packer, N., Stubbs, K.A., Williams, S.J., Dell, A. ‘Letter to the glycoforum transforming glycoscience: an Australian perspective’, Glycobiology, 2014,24, 1-3. [doi link].